Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Relaxin Family Peptide Receptors RXFP3 and RXFP4

  • Martina Kocan
  • Sheng Yu Ang
  • Roger J. SummersEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_583


Historical Background: Relaxin Family Peptides and Their Receptors

Relaxin family peptides including the relaxins 1–3, insulin-like peptides (INSL) 3–6, and insulin-like growth factors I and II have a similar architecture to insulin. In the human, three independent genes produce three relaxin peptides, named relaxin-1, relaxin, and the most recently discovered relaxin-3 (Bathgate et al. 2013a; Halls et al. 2015). Relaxin-3 is classified by the presence of the characteristic RxxxRxxI/V relaxin-binding motif in the B-chain but otherwise has relatively low sequence homology to other relaxin peptides. Compared to other relaxins, relaxin-3 is well conserved across species (Wilkinson et al. 2005a; Yegorov et al. 2009), is believed to be the ancestral peptide (Wilkinson et al. 2005a), and in mammals is primarily a neuropeptide (Bathgate et al. 2002; Tanaka et al. 2005; Banerjee et al. 2010; Ma et al. 2007; McGowan et al. 2005; Ganella...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Martina Kocan
    • 1
  • Sheng Yu Ang
    • 2
  • Roger J. Summers
    • 2
    Email author
  1. 1.Neuropeptides Division, Florey Institute of Neuroscience and Mental Health and Department of Biochemistry and Molecular Biology, University of MelbourneParkvilleAustralia
  2. 2.Drug Discovery Biology, Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleAustralia