Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CCL3

  • Carlos Eduardo Repeke
  • Thiago Pompermaier Garlet
  • Carolina Favaro Francisconi
  • Daiana Broll
  • Ana Paula Favaro Trombone
  • Gustavo Pompermaier Garlet
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_579

Synonyms

Historical Background

CCL3 was initially described in 1988, as a partially purified 8-kDa protein doublet from conditioned medium of endotoxin-stimulated mouse macrophages. In the view of its prominent proinflammatory chemotactic role, characterized both in vivo and in vitro at that time, this protein was denominated “macrophage inflammatory protein-1 alpha” (MIP-1α). Subsequently, a high nucleotide sequence similarity (69%) was found between the murine MIP-1α cDNA and a reported human cDNA cloned from stimulated lymphocytes, initially called LD78α or GOS19, assuming to be the human counterpart to murine MIP-1α (Wolpe et al. 1988; Menten et al. 2002; Maurer and von Stebut 2004). Interestingly, human and murine MIP-1α have been independently isolated in many laboratories in relatively short time span and has been named differently by each group. Similarly, several other cytokines with chemotactic abilities were identified, leading to...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Carlos Eduardo Repeke
    • 1
  • Thiago Pompermaier Garlet
    • 2
  • Carolina Favaro Francisconi
    • 3
  • Daiana Broll
    • 4
  • Ana Paula Favaro Trombone
    • 5
  • Gustavo Pompermaier Garlet
    • 3
  1. 1.PPGCAS Lab, Department of Dentistry of LagartoFederal University of Sergipe – DOL/UFSLagartoBrazil
  2. 2.Department of Structural and Molecular Biology and GeneticsState University of Ponta GrossaPonta GrossaBrazil
  3. 3.OSTEOimmunology lab, Department of Biological Sciences, School of Dentistry of BauruSão Paulo University, FOB/USPBauruBrazil
  4. 4.PPGCSFederal Unversity of SergipeSão CristóvãoBrazil
  5. 5.Universidade do Sagrado Coração (USC)BauruBrazil