CLEC-2 is a 32 kDa C-type lectin-like immune receptor (Colonna et al. 2000; O’Callaghan 2009). CLEC-2 (gene name CLEC1B) is part of the NK (natural killer) gene cluster found on human chromosome 12 and mouse chromosome 6. Within this cluster, CLEC-2 is part of the Dectin-1 subfamily which consists of all type 2 transmembrane proteins with extracellular C-type lectin-like domains (CTLDs) and immune or homeostatic roles. Other members of this cluster include: CLEC-1, Dectin-1, CLEC8A (Lox-1), CLEC9A, CLEC12A, and CLEC12B.
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