Reference work entry
CLEC-1 is a C-type lectin-like molecule. Based on its protein sequence, it is predicted to be a type 2 transmembrane protein with an N-terminal cytoplasmic tail, a single transmembrane domain, and a C-terminal extracellular C-type lectin-like domain, that is separated from the transmembrane domain by a short stalk region. The cytoplasmic domain contains a tyrosine residue within the sequence YSST, which may represent a novel signaling motif (Fig. 1). CLEC-1 is encoded within the natural killer gene complex on human chromosome 12 and mouse chromosome 6 in a cluster of genes termed the Dectin-1 cluster, which also includes MICL, CLEC-2, CLEC12B, CLEC9A, Dectin-1, and LOX-1. Like other Dectin-1 family members, CLEC-1 is predominantly expressed by dendritic cells (DC), endothelial cells, monocytes, and macrophages. Expression of...
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