Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

PKD

  • Peter Storz
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_533

Synonyms

Historical Background

The serine/threonine protein kinase D (PKD) was first described in 1994. Due to some homology in its kinase domain, its ability to bind the lipid diacylglycerol (DAG), and its responsiveness to phorbol ester, PKD was originally classified as a member of the protein kinase C (PKC) family (Johannes et al. 1994). Later, it became evident that PKD represents an own group of kinases more closely related to the calcium/calmodulin-regulated (Cam) kinases (Manning et al. 2002). Initially, the PKD field focused on determining the functions of the structural elements and domains of PKD1 as well as the activation mechanisms for this kinase. With the identification of the PKD phosphorylation motif (Hutti et al. 2004) and the subsequent generation of a substrate-specific antibody (Döppler et al. 2005), optimal conditions were provided for the discovery of PKD substrates. This led to an increasing wealth of...

This is a preview of subscription content, log in to check access.

References

  1. Baron CL, Malhotra V. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science. 2002;295(5553):325–8.CrossRefPubMedGoogle Scholar
  2. Borges S, Döppler H, Perez EA, Andorfer CA, Sun Z, Anastasiadis PZ, Thompson EA, Geiger XJ, Storz P. Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. Breast Cancer Res. 2013;15(2):R66. http://www.ncbi.nlm.nih.gov/pubmed/23971832
  3. Cowell CF, Döppler H, Yan IK, Hausser A, Umezawa Y, Storz P. Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling. J Cell Sci. 2009;122(Pt 7):919–28.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Döppler H, Storz P. A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation. J Biol Chem. 2007;282(44):31873–81.CrossRefPubMedGoogle Scholar
  5. Döppler H, Storz P, Li J, Comb MJ, Toker A. A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem. 2005;280(15):15013–9.CrossRefPubMedGoogle Scholar
  6. Durand N, Borges S, Storz P. Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer. Cell Mol Life Sci. 2015;72(22):4369–82. http://www.ncbi.nlm.nih.gov/pubmed/26253275PubMedPubMedCentralCrossRefGoogle Scholar
  7. Eiseler T, Döppler H, Yan IK, Kitatani K, Mizuno K, Storz P. Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat Cell Biol. 2009;11(5):545–56.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Fugmann T, Hausser A, Schoffler P, Schmid S, Pfizenmaier K, Olayioye MA. Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol. 2007;178(1):15–22.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Ghanekar Y, Lowe M. Protein kinase D: activation for Golgi carrier formation. Trends Cell Biol. 2005;15(10):511–4.CrossRefPubMedGoogle Scholar
  10. Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, et al. Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. J Biol Chem. 1999;274(14):9258–64.CrossRefPubMedGoogle Scholar
  11. Hausser A, Storz P, Martens S, Link G, Toker A, Pfizenmaier K. Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat Cell Biol. 2005;7(9):880–6.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, et al. A rapid method for determining protein kinase phosphorylation specificity. Nat Methods. 2004;1(1):27–9.CrossRefPubMedGoogle Scholar
  13. Johannes FJ, Prestle J, Eis S, Oberhagemann P, Pfizenmaier K. PKCu is a novel, atypical member of the protein kinase C family. J Biol Chem. 1994;269(8):6140–8.PubMedGoogle Scholar
  14. Kim M, Jang HR, Kim JH, Noh SM, Song KS, Cho JS, et al. Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis. 2008;29(3):629–37.CrossRefPubMedGoogle Scholar
  15. Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun. 2015;6:6200. http://www.ncbi.nlm.nih.gov/pubmed/25698580
  16. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002;298(5600):1912–34.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Matthews SA, Rozengurt E, Cantrell D. Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/protein kinase Cmu. J Biol Chem. 1999;274(37):26543–9.CrossRefPubMedGoogle Scholar
  18. Rozengurt E, Rey O, Waldron RT. Protein kinase D signaling. J Biol Chem. 2005;280(14):13205–8.CrossRefPubMedGoogle Scholar
  19. Sanchez-Ruiloba L, Cabrera-Poch N, Rodriguez-Martinez M, Lopez-Menendez C, Jean-Mairet RM, Higuero AM, et al. Protein kinase D intracellular localization and activity control kinase D-interacting substrate of 220-kDa traffic through a postsynaptic density-95/discs large/zonula occludens-1-binding motif. J Biol Chem. 2006;281(27):18888–900.CrossRefPubMedGoogle Scholar
  20. Storz P, Toker A. Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J. 2003;22(1):109–20.PubMedPubMedCentralCrossRefGoogle Scholar
  21. Van Lint J, Rykx A, Maeda Y, Vantus T, Sturany S, Malhotra V, et al. Protein kinase D: an intracellular traffic regulator on the move. Trends Cell Biol. 2002;12(4):193–200.CrossRefPubMedGoogle Scholar
  22. Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN, et al. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol. 2004;24(19):8374–85.PubMedPubMedCentralCrossRefGoogle Scholar
  23. Wang QJ. PKD at the crossroads of DAG and PKC signaling. Trends Pharmacol Sci. 2006;27(6):317–23.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Cancer BiologyMayo Clinic Comprehensive Cancer CenterJacksonvilleUSA