Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

TMEM85 (Transmembrane Protein 85)

  • Michael T. Greenwood
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_532

Synonyms

Historical Background

Prior to 2008, there were no publications on the TMEM85 gene or protein. The GenBank and Entrez Gene databases described TMEM85 as an evolutionary conserved transmembrane domain containing protein (DUF1077 superfamily motif) found in all eukaryotes examined ( TMEM85 (Transmembrane Protein 85)). In the yeast Saccharomyces cerevisiae, the TMEM85 orthologue is called YGL231c. In 2003, it was reported that yeast cells lacking YGL231c showed an increased sensitivity to the toxic effects of ectopically expressed Parkinson’s disease associated gene α-synuclein (Willingham et al. 2003). Finally, the analysis of a GFP tagged genomic copy of YGL231c suggests that the protein is a resident of the endoplasmic reticulum (ER) (YGL231c-gene).

TMEM85, An Anti-Apoptotic Gene

By screening a human heart cDNA expression library in yeast cell undergoing apoptosis due to the ectopic expression of a cDNA...

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References

  1. Bossers K, Meerhoff G, Balesar R, van Dongen JW, Kruse CG, Swaab DF, Verhaagen J. Analysis of gene expression in Parkinson’s disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathol. 2009;19:91–107.PubMedPubMedCentralGoogle Scholar
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  5. Saccharomyces Genome Database for the YGL231c gene. http://www.yeastgenomeorg/cgi-bin/locusfpl?locus=YGL231C. Accessed 5 April 2011.Google Scholar
  6. The Entez Gene web page for the TMEM85 gene. http://www.ncbinlmnihgov/gene/51234. Accessed 5 April 2011.
  7. The Universal Protein Resource (UniProt) web page for the human TMM85 protein http://www.uniprot.org/uniprot/Q5J8M3. Accessed 5 April 2011.
  8. Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science. 2003;302:1769–72.PubMedPubMedCentralGoogle Scholar
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Chemistry and Chemical EngineeringRoyal Military College of CanadaKingstonCanada