MOZ and MORF Lysine Acetyltransferases
Reference work entry
MOZ is a founding member of the MYST ( MOZ, YBF2, SAS2, and TIP60) family of lysine acetyltransferases (Borrow et al. 1996; Reifsnyder et al. 1996; reviewed in Yang and Ullah 2007). It was identified in 1996 through positional cloning of the reciprocal chromosomal t(8;16)(p11;p13) translocation with CREB-binding protein (CBP) associated with a subset of acute myeloid leukemia (AML) (Borrow et al. 1996). A few years later, the acetyltransferase activity was demonstrated and mapped to the MYST domain (Champagne et al. 2001; Kitabayashi et al. 2001a). Human MORF was identified in BLAST search against expressed sequence tag databases for additional MYST proteins (Champagne et al. 1999). Mouse Morf was also identified as Querkopf, a mutant allele causing craniofacial abnormalities...
This research was supported by operating grants from Canadian Institutes of Health Research (CIHR) and Canadian Cancer Society (to X. J. Y.).
- Borrow J, Stanton Jr VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dube I, Frischauf AM, et al. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet. 1996;14:33–41.CrossRefPubMedGoogle Scholar
- Camos M, Esteve J, Jares P, Colomer D, Rozman M, Villamor N, Costa D, Carrio A, Nomdedeu J, Montserrat E, et al. Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression. Cancer Res. 2006;66:6947–54.CrossRefPubMedGoogle Scholar
- Ichikawa M, Asai T, Saito T, Seo S, Yamazaki I, Yamagata T, Mitani K, Chiba S, Ogawa S, Kurokawa M, et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med. 2004;10:299–304.CrossRefPubMedGoogle Scholar
- Ohta K, Ohigashi M, Naganawa A, Ikeda H, Sakai M, Nishikawa J, Imagawa M, Osada S, Nishihara T. Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. Biochem J. 2007;402:559–66.PubMedPubMedCentralCrossRefGoogle Scholar
- Sato Y, Bohlander SK, Kobayashi H, Reshmi S, Suto Y, Davis EM, Espinosa R, Hoopes R, Montgomery KT, Kucherlapati RS, et al. Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half. Blood. 1997;90:4886–93.PubMedGoogle Scholar
- Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, et al. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Proc Natl Acad Sci U S A. 2002;99:11836–41.PubMedPubMedCentralCrossRefGoogle Scholar
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