Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Anthony John SadlerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_51


Historical Background

Protein kinase R (PKR) was identified through its function in regulating host protein synthesis during virus infection (Farrell et al. 1977; Metz and Esteban 1972). This regulation is enacted through phosphorylation of the eukaryotic initiation factor 2α (EIF2α), marking PKR as a member of a small kinase family that constitutes this universal stress response pathway in eukaryotes (Roberts et al. 1976). A number of additional protein substrates for PKR have been identified, although the consequence of this is not well characterized. The transcript’s cDNA was cloned and the...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre for Cancer ResearchHudson Institute of Medical ResearchClaytonAustralia
  2. 2.Department of Molecular and Translational ScienceMonash UniversityClaytonAustralia