Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

P2Y14 Receptor

  • Kenneth A. JacobsonEmail author
  • Ramachandran Balasubramanian
  • Antonella Ciancetta
  • Zhan-Guo Gao
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_471


Historical Background

Extracellular purine and pyrimidine nucleotides act as signaling molecules through the activation of P2X ion channels and P2Y G protein-coupled receptors (GPCRs) (Abbracchio et al. 2006). Among the eight members of the P2Y receptor family, four respond to extracellular uracil nucleotides: P2Y2, P2Y4, P2Y6, and P2Y14 receptors. None of the P2X ion channels are substantially activated by uracil nucleotides.

P2Y 2, P2Y 4, and P2Y 6 receptors belong to the P2Y 1-like subgroup of G q-coupled receptors, and the P2Y 14 receptor belongs to the P2Y 12-like subgroup that couples to  G protein αi to inhibit  adenylyl cyclase. The P2Y 14 receptor is distributed in various tissues, that is, placenta, adipose, stomach, intestine, spleen, thymus, lung, heart, mast cells, and discrete brain regions (Freeman et al. 2001; Harden et al. 2010). It is activated by uridine-5′-diphosphoglucose (UDPG, 1, Fig. 1), other endogenous UDP-sugars, and...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Kenneth A. Jacobson
    • 1
    Email author
  • Ramachandran Balasubramanian
    • 1
  • Antonella Ciancetta
    • 1
  • Zhan-Guo Gao
    • 1
  1. 1.Laboratory of Bioorganic Chemistry and Molecular Recognition SectionNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthBethesdaUSA