Skip to main content
SpringerLink
Log in

ITPK1 (Inositol Tetrakisphosphate 1-Kinase)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 62 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Balla T, Guillemette G, Baukal AJ, Catt K. Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells. J Biol Chem. 1987;262:9952–5.

    CAS  PubMed  Google Scholar 

  • Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, et al. Integration of inositol phosphate signaling pathways via human ITPK1. J Biol Chem. 2007;282:28117–25.

    Article  PubMed  CAS  Google Scholar 

  • Ferrera L, Caputo A, Galietta LJ. TMEM16A protein: a new identity for Ca(2+)-dependent Cl channels. Physiology (Bethesda). 2010;25:357–63.

    CAS  Google Scholar 

  • Ganapathi SB, Wei S-G, Lamb FS, Shears SB. Functional regulation of ClC-3 in the migration of vascular smooth muscle cells. Hypertension. 2013;61:174–9.

    Article  CAS  PubMed  Google Scholar 

  • Guan Z, Wang J, Guo J, Wang F, Wang X, Li G, et al. The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population. PLoS One. 2014;9:e86145.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ho MWY, Yang X, Carew MA, Zhang T, Hua L, Kwon Y-U, et al. Regulation of Ins(3456)P4 signaling by a reversible kinase/phosphatase. Curr Biol. 2002;12:477–82.

    Article  CAS  PubMed  Google Scholar 

  • Ho MWY, Kaetzel MA, Armstrong DL, Shears SB. Regulation of a human chloride channel: a paradigm for integrating input from calcium, CaMKII and Ins(3,4,5,6)P4. J Biol Chem. 2001;276:18673–80.

    Article  CAS  PubMed  Google Scholar 

  • Miller GJ, Wilson MP, Majerus PW, Hurley JH. Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. Mol Cell. 2005;18:201–12.

    Article  CAS  PubMed  Google Scholar 

  • Mitchell J, Wang X, Zhang G, Gentzsch M, Nelson DJ, Shears SB. An expanded biological repertoire for Ins(3,4,5,6)P(4) through its modulation of ClC-3 function. Curr Biol. 2008;18:1600–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Qian X, Mitchell J, Wei SJ, Williams J, Petrovich RM, Shears SB. The Ins(1,3,4)P3 5/6-kinase / Ins(3,4,5,6)P4 1-kinase is not a protein kinase. Biochem J. 2005;389:389–95.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Renström E, Ivarsson R, Shears SB. Ins(3,4,5,6)P4 inhibits insulin granule acidification and fusogenic potential. J Biol Chem. 2002;277:26717–20.

    Article  CAS  PubMed  Google Scholar 

  • Riley AM, Deleu S, Qian X, Mitchell J, Chung SK, Adelt S, et al. On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P(4) is not a physiologic substrate. FEBS Lett. 2006;580:324–30.

    Article  CAS  PubMed  Google Scholar 

  • Shears SB. The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase. J Biol Chem. 1989;264:19879–86.

    CAS  PubMed  Google Scholar 

  • Shears SB, Parry JB, Tang EKY, Irvine RF, Michell RH, Kirk CJ. Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate. Biochem J. 1987;246:139–47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vajanaphanich M, Schultz C, Rudolf MT, Wasserman M, Enyedi P, Craxton A, et al. Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4. Nature. 1994;371:711–4.

    Article  PubMed  CAS  Google Scholar 

  • Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW. The pathway for the production of inositol hexakisphosphate in human cells. J Biol Chem. 2005;280:1911–20.

    Article  PubMed  CAS  Google Scholar 

  • Wilson MP, Hugge C, Bielinska M, Nicholas P, Majerus PW, Wilson DB. Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Proc Natl Acad Sci USA. 2009;106:9831–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilson MP, Majerus PW. Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning, and expression of recombinant enzyme. J Biol Chem. 1996;271:11904–10.

    Article  CAS  PubMed  Google Scholar 

  • Wilson MP, Sun Y, Cao L, Majerus PW. Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-jun and ATF-2. J Biol Chem. 2001;276:40998–1004.

    Article  CAS  PubMed  Google Scholar 

  • Xie W, Solomons KRH, Freeman S, Kaetzel MA, Bruzik KS, Nelson DJ, et al. Regulation of Ca2+-dependent Cl− conductance in T84 cells: cross-talk between Ins(3,4,5,6)P4 and protein phosphatases. J Physiol Lond. 1998;510:661–73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yang X, Shears SB. Multitasking in Signal Transduction by a Promiscuous Human Ins(3,4,5,6)P4 1-Kinase/Ins(1,3,4)P3 5/6-Kinase. Biochem J. 2000;351:551–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhou Y, Wu S, Wang H, Hayakawa Y, Bird GS, Shears SB. Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1. Biochem J. 2012;448:273–83.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Durham, NC, USA

    Yixing Zhou

  2. Laboratory of Signal Transduction, Inositol Signaling Section, National Institute of Environmental Health Sciences (NIEHS/NIH), Lukasstr. 16b, 50823, Koeln, Germany

    Tobias M. H. Schenk

  3. Laboratory of Signal Transduction, Inositol Signaling Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA

    Stephen B. Shears

Authors
  1. Yixing Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tobias M. H. Schenk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen B. Shears
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephen B. Shears .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Zhou, Y., Schenk, T.M.H., Shears, S.B. (2018). ITPK1 (Inositol Tetrakisphosphate 1-Kinase). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_457

Download citation

Publish with us

Policies and ethics

Search

Navigation