Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive sphingolipid metabolite. Sphingolipids are essential structural constituents of the plasma membrane of all eukaryotic organisms and are also produced by some bacteria. In response to a wide range of stressful stimuli, membrane sphingomyelin and to lesser extent other complex sphingolipids are rapidly metabolized to the bioactive sphingolipid intermediate, ceramide and subsequently to sphingosine (Hannun and Obeid 2008). Phosphorylation of sphingosine by two sphingosine kinases (SphKs) results in the formation of S1P. It has emerged as a potent signaling molecule that regulates diverse cellular processes including cell proliferation, survival, differentiation, and migration (Spiegel and Milstien 2003). S1P plays a critical role in several physiological processes including...
- Borodzicz S, Czarzasta K, Kuch M, Cudnoch-Jedrzejewska A. Sphingolipids in cardiovascular diseases and metabolic disorders. Lipids Health Dis. 2015;14:55. doi:10.1186/s12944-015-0053-y. Epub 2015/06/17. PubMed PMID: 26076974; PubMed Central PMCID: PMC4470334.CrossRefPubMedPubMedCentralGoogle Scholar
- Degagne E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, et al. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014;124(12):5368–84. doi:10.1172/JCI74188. Epub 2014/10/28. PubMed PMID: 25347472; PubMed Central PMCID: PMC4348973.CrossRefPubMedPubMedCentralGoogle Scholar
- Kassmer SH, Rodriguez D, Langenbacher AD, Bui C, De Tomaso AW. Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. Nat Commun. 2015;6:8565. doi:10.1038/ncomms9565. Epub 2015/10/13. PubMed PMID: 26456232; PubMed Central PMCID: PMC4606877.CrossRefPubMedPubMedCentralGoogle Scholar