Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Ashok KumarEmail author
  • Julie D. Saba
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_452



Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive sphingolipid metabolite. Sphingolipids are essential structural constituents of the plasma membrane of all eukaryotic organisms and are also produced by some bacteria. In response to a wide range of stressful stimuli, membrane sphingomyelin and to lesser extent other complex sphingolipids are rapidly metabolized to the bioactive sphingolipid intermediate, ceramide and subsequently to sphingosine (Hannun and Obeid 2008). Phosphorylation of sphingosine by two sphingosine kinases (SphKs) results in the formation of S1P. It has emerged as a potent signaling molecule that regulates diverse cellular processes including cell proliferation, survival, differentiation, and migration (Spiegel and Milstien 2003). S1P plays a critical role in several physiological processes including...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiochemistryAll India Institute of Medical SciencesBhopalIndia
  2. 2.Center for Cancer ResearchUCSF Benioff Children’s Hospital OaklandOaklandUSA