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ITSN

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 37 Accesses

Synonyms

Ese; Intersectin

The Intersectin Family

The Intersectin family refers to a group of proteins that share N-terminal EH domains, a central coiled-coil domain, and multiple SH3 domains. In mammals, there are Intersectin1 and 2 genes (Itsn1 and Itsn2, respectively), whereas in invertebrates, only one gene appears to be present.

Historical Background

Intersectins are conserved modular scaffold proteins with two Eps15-homology (EH) domains, an extended KLERQ coiled-coil domain, four or five Src-homology 3 (SH3) domains, and, in some vertebrate splice variants, DBL/PH and C2 domains (Fig. 1). The Itsn proteins were discovered independently in a number of organisms and in a number of labs. For example, the single Itsn in Drosophila melanogaster, Dap160, or Dynamin-associated protein 160 kDa, copurified with the proline-rich C-terminus of Dynamin (Roos and Kelly 1998). Human ITSN1 was cloned following identification of a trapped exon that coded for a novel EH domain (Guipponi et al. 1998...

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Authors and Affiliations

  1. Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada

    Ameet S. Sengar & Michael W. Salter

  2. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada

    Sean E. Egan

Authors
  1. Ameet S. Sengar
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  2. Michael W. Salter
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  3. Sean E. Egan
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Correspondence to Sean E. Egan .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Sengar, A.S., Salter, M.W., Egan, S.E. (2018). ITSN. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_440

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