Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ITSN

  • Ameet S. Sengar
  • Michael W. Salter
  • Sean E. Egan
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_440

Synonyms

The Intersectin Family

The Intersectin family refers to a group of proteins that share N-terminal EH domains, a central coiled-coil domain, and multiple SH3 domains. In mammals, there are Intersectin1 and 2 genes (Itsn1 and Itsn2, respectively), whereas in invertebrates, only one gene appears to be present.

Historical Background

Intersectins are conserved modular scaffold proteins with two Eps15-homology (EH) domains, an extended KLERQ coiled-coil domain, four or five Src-homology 3 (SH3) domains, and, in some vertebrate splice variants, DBL/PH and C2 domains (Fig. 1). The Itsn proteins were discovered independently in a number of organisms and in a number of labs. For example, the single Itsn in Drosophila melanogaster, Dap160, or Dynamin-associated protein 160 kDa, copurified with the proline-rich C-terminus of Dynamin (Roos and Kelly 1998). Human ITSN1 was cloned following identification of a trapped exon that coded for a novel EH domain (Guipponi et al. 1998...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Ameet S. Sengar
    • 1
  • Michael W. Salter
    • 1
  • Sean E. Egan
    • 2
  1. 1.Program in Neurosciences and Mental HealthThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Program in Developmental and Stem Cell BiologyThe Hospital for Sick ChildrenTorontoCanada