Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Scott A. NessEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_439


Historical Background

The c-Myb protein is a DNA-binding transcription factor that regulates the expression of other genes; controls the proliferation and differentiation of hematopoietic, epithelial, and neural cells; and can be mutated into an oncogenic form that induces leukemias and other tumors in animals and humans (Zhou and Ness 2011) (Note: I use c-Myb and MYB to distinguish between the protein and gene, respectively. Readers are encouraged to consult the cited review articles for links to the primary literature, which cannot be listed here due to limitations on space and the number of citations). The MYB gene is the normal counterpart to two v- myb oncogenes encoded by avian leukemia viruses that induce leukemias in animals and transform immature hematopoietic cells in tissue culture (Lipsick and Wang 1999; Ness 2003; Zhou and Ness 2011). Avian myeloblastosis virus (AMV) encodes a v-Myb protein that when compared to...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Molecular Medicine and UNM Comprehensive Cancer CenterUniversity of New MexicoAlbuquerqueUSA