Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Balachandran Manavalan
  • Shaherin Basith
  • Sangdun ChoiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_436


Historical Background

IκBζ is also known as molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL) or interleukin (IL)-1 inducible nuclear ankyrin-repeat protein (INAP) and it was first discovered independently in two laboratories during 2000 as a protein containing ankyrin repeats. The gene encodes a protein with an amino-terminal region of 450 amino acids that contains a nuclear localization signal (NLS) and a transactivation domain (TAD) followed by the seven recognizable ankyrin repeats at its carboxyl terminal. Treatment of cells with lipopolysaccharides (LPS) or the cytokine interleukin (IL)-1...

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This work was supported by the National Research Foundation of Korea (NRF-2015R1A2A2A09001059).


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Balachandran Manavalan
    • 1
    • 2
  • Shaherin Basith
    • 1
    • 3
  • Sangdun Choi
    • 1
    Email author
  1. 1.Department of Molecular Science and TechnologyAjou UniversitySuwonKorea
  2. 2.Center for In Silico Protein Science, School of Computational SciencesKorea Institute for Advanced StudySeoulKorea
  3. 3.National Leading Research Laboratory (NLRL) of Molecular Modeling and Drug Design, College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulKorea