IkappaBzeta; IkB-zeta; IL-1 inducible nuclear ankyrin-repeat protein (INAP); Inap; Mail; Molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL); Molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKBIZ; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
IκBζ is also known as molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL) or interleukin (IL)-1 inducible nuclear ankyrin-repeat protein (INAP) and it was first discovered independently in two laboratories during 2000 as a protein containing ankyrin repeats. The gene encodes a protein with an amino-terminal region of 450 amino acids that contains a nuclear localization signal (NLS) and a transactivation domain (TAD) followed by the seven recognizable ankyrin repeats at its carboxyl terminal. Treatment of cells with lipopolysaccharides (LPS) or the cytokine interleukin (IL)-1...
This work was supported by the National Research Foundation of Korea (NRF-2015R1A2A2A09001059).