Reference work entry
Sterile-alpha motif and leucine zipper-containing kinase AZK (ZAK) is a protein kinase that belongs to the family of mitogen-activated protein kinase kinase kinases (MAPKKK) with closer homology to the MLK proteins (Gallo and Johnson 2002), with which it shares 40% sequence identity in its kinase domain. It was isolated as ZAK by low-stringent hybridization to the Ste20 kinase (Liu et al. 2000); as MLK7, a gene highly expressed in the heart (Bloem et al. 2001); as MLTK, a gene induced by overexpression of active ERK (Gotoh et al. 2001); and as MRK, a human gene that acts as a MAPKKK in a yeast functional screen (Gross et al. 2002). The ZAK gene encodes two splice variants: ZAKα and ZAKβ of 91.7 kDa and 51.3 kDa calculated molecular mass, respectively (Gross et al. 2002)....
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