Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Chemokine Receptor CCR1

  • Richard HorukEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_406


 CCR-1;  CD191;  CC-CKR-1;  CKR1;  CMKBR1;  HM145;  MIP1aR


Chemokines represent a large group of chemotactic proteins, with more than 50 members that regulate the trafficking and activation of immune cells. They mediate their activity by binding to cell surface chemokine receptors that belong to the G-protein coupled receptor (GPCR) superfamily. CCR1 is a chemokine receptor that responds to a large number of CC chemokines including CCL3 (MIP-1alpha), CCL5 (RANTES), CCL7 (MCP-3), CCL9 (MIP-1gamma), CCL15 (MIP1 delta), CCL23 (MIP-3), and with low affinity to CCL4 (MIP-1 beta) and CCL8 (MCP-2).

Structure and Functions

Human CCR1 is a serpentine protein comprising of 355 amino acids with three potential glycosylation sites and the characteristic seven membrane spanning architecture typical of GPCR’s (Fig. 1). The receptor has a consensus site for tyrosine sulfation, which affects the affinity and binding of some chemokine receptors to their ligand(s) and has been...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PharmacologyUC DavisDavisUSA