Historical Background
Formyl peptide receptor 1 (FPR1) was first discovered on human neutrophils through its ability to bind N-formylated peptides with high affinity (Schiffmann et al. 1975). Rabbit neutrophils exhibit similar binding properties. The 350-amino acid human FPR1 receptor was the first cloned leukocyte chemoattractant receptor (Boulay et al. 1990). Genes with homologous sequence (FPR2 and FPR3) were identified through low-stringency hybridization using the FPR1 cDNA. The FPR2 cDNA encodes a 351-residue protein and shares approximately 69% sequence identity with FPR1. FPR2 is a low-affinity receptor for the prototypic formyl peptide, N-formyl-Met-Leu-Phe (fMLF). It binds lipoxin A4 and therefore is termed FPR2/ALX (Ye et al. 2009). FPR3 encodes a 7TM receptor of 352 amino acids that shares 56% sequence identity with FPR1 but does not bind fMLF. Although these three human members of the formyl peptide receptor family are relatively similar in terms...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW. Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature. 1991;353(6345):668–70.
Babior BM, Lambeth JD, Nauseef W. The neutrophil NADPH oxidase. Arch Biochem Biophys. 2002;397(2):342–4.
Bokoch GM. Chemoattractant signaling and leukocyte activation. Blood. 1995;86(5):1649–60.
Borregaard N. Development of neutrophil granule diversity. Ann N Y Acad Sci. 1997;832:62–8.
Boulay F, Tardif M, Brouchon L, Vignais P. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem Biophys Res Commun. 1990;168:1103–9.
Boxer LA, Yoder M, Bonsib S, Schmidt M, Ho P, Jersild R, et al. Effects of a chemotactic factor, N-formylmethionyl peptide, on adherence, superoxide anion generation, phagocytosis, and microtubule assembly of human polymorphonuclear leukocytes. J Lab Clin Med. 1979;93(3):506–14.
Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, et al. PTEN functions to ‘prioritize’ chemotactic cues and prevent ‘distraction’ in migrating neutrophils. Nat Immunol. 2008;9(7):743–52.
Korchak HM, Wilkenfeld C, Rich AM, Radin AR, Vienne K, Rutherford LE. Stimulus response coupling in the human neutrophil. Differential requirements for receptor occupancy in neutrophil responses to a chemoattractant. J Biol Chem. 1984;259(12):7439–45.
Le Y, Murphy PM, Wang JM. Formyl-peptide receptors revisited. Trends Immunol. 2002;23(11):541–8.
Marasco WA, Phan SH, Krutzsch H, Showell HJ, Feltner DE, Nairn R, et al. Purification and identification of formyl-methionyl-leucyl- phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J Biol Chem. 1984;259:5430–9.
Migeotte I, Communi D, Parmentier M. Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev. 2006;17(6):501–19.
Prossnitz ER. Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation. J Biol Chem. 1997;272(24):15213–9.
Prossnitz ER, Ye RD. The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function. Pharmacol Ther. 1997;74(1):73–102.
Rabiet MJ, Huet E, Boulay F. Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur J Immunol. 2005;35(8):2486–95.
Rabiet MJ, Huet E, Boulay F. The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview. Biochimie. 2007;89(9):1089–106.
Schiffmann E, Corcoran BA, Wahl SM. N-formylmethionyl peptides as chemoattractants for leucocytes. Proc Natl Acad Sci U S A. 1975;72:1059–62.
Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, et al. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell. 2002;108(6):809–21.
Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, et al. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell. 2003;114(2):201–14.
Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, et al. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev. 2009;61(2):119–61.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Southgate, E.L., Ye, R.D. (2018). Formyl Peptide Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_403
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_403
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences