Reference work entry
The two members of the LIM kinase (LIMK) family of proteins include LIMK1 and LIMK2. LIMK1, the first of these unique serine kinases to be characterized, was also identified as the murine Kiz-1 protein (Bernard et al. 1994). The second highly related family member, LIMK2, was cloned using a LIMK1 cDNA probe (Okano et al. 1995). These two LIMK family members have identical genomic structures with 16 exons and identical intron/exon boundaries (Bernard et al. 1996; Ikebe et al. 1997). They share a total of ∼50% amino acid sequence identity with ∼70% identity in their kinase domain (Okano et al. 1995). The structure of the LIMK proteins is unique as they contain two different protein–protein interaction domains, namely, LIM (Lin 11, Isl 1, Mec 3) and PDZ (PSD-95, Dlg, ZO-1) domains. Two tandem LIM domains lie at the N-terminal followed by a central PDZ domain. These two domains are separated from the...
- Scott RW, Hooper S, Crighton D, Li A, Konig I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol. 2010;191:169–85.PubMedPubMedCentralCrossRefGoogle Scholar
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