FRS2 stands for fibroblast growth factor (FGF) receptor substrate 2. The FGF receptor substrate 1 is phospholipase (PLC) γ, which was identified as the first substrate of FGF receptor tyrosine kinases (Gotoh et al. 2004). Historically, SNT was identified as a protein that is tyrosine phosphorylated in response to nerve growth factor (NGF) or FGF in PC12 cells and can bind to p13suc1, a yeast cyclin–dependent kinase binding protein, immobilized on agarose (Rabin et al. 1993). It was reported that there is a good correlation between the tyrosine phosphorylation of SNT and differentiation of PC12 cells. Then FRS2 was purified and cloned as a novel protein that is tyrosine phosphorylated in NIH3T3 cells in response to FGF (Kouhara et al. 1997). It turned out to be the same protein as SNT. Another protein that...
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