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Encyclopedia of Signaling Molecules pp 912–919Cite as

CD45 (PTPRC)

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Synonyms

B220; CD45R; Ly 5.2; Ly5.1; Protein tyrosine phosphatase receptor type C; T200; The leukocyte common antigen (LCA)

Historical Background

CD45 was first identified by antisera and then by monoclonal antibodies (mAbs) as a major lymphocyte cell surface glycoprotein. CD45 is leukocyte specific, expressed on all hematopoietic cells except red blood cells and this has led to the clinical use of pan-specific CD45 mAbs to identify leukocytes and cells of hematopoietic origin. Some mAbs identify specific isoforms of CD45 that are expressed in a cell type and developmentally regulated manner and are referred to as CD45R mAbs. CD45 isoforms range from 180 to 220 kDa and cloning of the CD45 gene revealed that these isoforms arise by alternative splicing of at least three exons (ABC) that encode a region near the amino terminus of the extracellular domain of CD45 (Thomas 1989; Johnson et al. 1997). The B220 (CD45RABC) isoform of CD45 is expressed primarily on B cells and the CD45RA and...

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References

  • Alexander D. The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function. Semin Immunol. 2000;12:349–59.

    Article  PubMed  CAS  Google Scholar 

  • Dustin ML, Chakraborty AK, Shaw AS. Understanding the structure and function of the immunological synapse. Cold Spring Harb Perspect Biol. 2010;2:a002311.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hermiston M, Xu Z, Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol. 2003;21:107–37.

    Article  PubMed  CAS  Google Scholar 

  • Hermiston ML, Tan AL, Gupta VA, Majeti R, Weiss A. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity. 2005;23:635–47.

    Article  PubMed  CAS  Google Scholar 

  • Hermiston M, Zikherman J, Zhu JW. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev. 2009;228:288–311.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hibbs ML, Harder KW. The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling. Growth Factors. 2006;24:137–49.

    Article  PubMed  CAS  Google Scholar 

  • Huntington ND, Tarlinton DM. CD45: direct and indirect government of immune regulation. Immunol Lett. 2004;94:167–74.

    Article  PubMed  CAS  Google Scholar 

  • Johnson P, Cross JL. Tyrosine phosphorylation in immune cells: direct and indirect effects on toll-like receptor-induced proinflammatory cytokine production. Crit Rev Immunol. 2009;29:347–67.

    Article  PubMed  Google Scholar 

  • Johnson P, Felberg J. CD45: a key regulator of Lck and T cell activation. Mod Asp Immunobiol. 2000;1:156–9.

    Google Scholar 

  • Johnson P, Maiti A, DHW N. CD45: a family of leukocyte specific cell surface glycoproteins. In: Herzenberg LA, Weir DM, Herzenberg LA, Blackwell C, editors. Weir’s Handbook of experimental immunology. 5th ed. Malden: Blackwell; 1997. p. 62.1–62.16.

    Google Scholar 

  • Penninger JM, Irie-Sasaki J, Sasaki T, Oliveira-dos-Santos AJ. CD45: new jobs for an old acquaintance. Nat Immunol. 2001;2:389–96.

    Article  PubMed  CAS  Google Scholar 

  • Saunders AE, Johnson P. Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45. Cell Signal. 2010;22:339–48.

    Article  PubMed  CAS  Google Scholar 

  • Scapini P, Pereira S, Zhang H, Lowell CA. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev. 2009;228:23–40.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Thomas ML. The leukocyte common antigen family. Annu Rev Immunol. 1989;7:339–69.

    Article  PubMed  CAS  Google Scholar 

  • Tomlinson MG, Lin J, Weiss A. Lymphocytes with a complex: adapter proteins in antigen receptor signaling. Immunol Today. 2000;21:584–91.

    Article  PubMed  CAS  Google Scholar 

  • Trowbridge IS, Thomas ML. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu Rev Immunol. 1994;12:85–116.

    Article  PubMed  CAS  Google Scholar 

  • van der Merwe PA, Dushek O. Mechanisms for T cell receptor triggering. Nat Rev Immunol. 2011;11:47–55.

    Article  PubMed  CAS  Google Scholar 

  • Williams JC, Wierenga RK, Saraste M. Insights into Src kinase functions: structural comparisons. Trends Biochem Sci. 1998;23:179–84.

    Article  PubMed  CAS  Google Scholar 

  • Xu Y, Harder KW, Huntington ND, Hibbs ML, Tarlinton DM. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity. 2005;22:9–18.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada

    Pauline Johnson, Asanga Samarakoon, Amy E. Saunders & Kenneth W. Harder

Authors
  1. Pauline Johnson
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  2. Asanga Samarakoon
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  3. Amy E. Saunders
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  4. Kenneth W. Harder
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Corresponding author

Correspondence to Pauline Johnson .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Johnson, P., Samarakoon, A., Saunders, A.E., Harder, K.W. (2018). CD45 (PTPRC). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_34

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