Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

PSGR

  • Melissa Rodriguez
  • Stefan Siwko
  • Mingyao Liu
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_338

Synonyms

Historical Background

The prostate-specific G-protein-coupled receptor, PSGR, was first identified by three distinct laboratories using different experimental approaches (Xu et al. 2000; Xia et al. 2001; Yuan et al. 2001). The main purpose of the search was to find prostate-specific genes with potential diagnostic utility. PSGR was selected due to its prostate-specific expression and its overexpression in prostate cancer, which was suggestive of biomarker potential. Initial research on this molecule focused on its expression pattern, regulation, and probable role as a biomarker for prostate cancer. For an in-depth summary, please refer to the previous edition of this encyclopedia. Since then, research has emerged on the underlying mechanisms of its role in prostate cancer initiation and progression and its potential ligands. Herein we provide a review and update on the PSGR literature.

PSGR as a...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Mingyao Liu Lab Department of Molecular and Cellular MedicineInstitute of Biosciences and Technology, Texas A&M University Health Science CenterHoustonUSA
  2. 2.Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences, School of Life Sciences, East China Normal UniversityShanghaiChina