Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Nuclear Receptor-Interacting Protein 1 (NRIP1)

  • Bomi Lee
  • Ping-Chih Ho
  • Li-Na Wei
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_280

Synonyms

Historical Background

Determining the regulatory mechanisms of nuclear receptor action was one major focal topic of research in the 1990s. During this period, many nuclear receptor-associated proteins were identified as transcriptional coregulators, which were broadly categorized as coactivators and corepressors. Human receptor-interacting protein 140 (RIP140) was identified as a ligand-dependent interacting protein of estrogen receptor α (ERα) by far-Western blotting, and mouse RIP140 was isolated as a corepressor of orphan receptor TR2 from a yeast two-hybrid screening and later found to also interact with  retinoic acid receptor (RAR) in a ligand-enhanced manner (Lee et al. 1998). An official gene name nrip1was established for RIP140 by the HUGO gene nomenclature committee. The mouse gene is located on chromosome 16, in...

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Notes

Acknowledgments

This work was supported by DK54733, DK60521, DK54733-11S, DK60521-12S1, Dean’s Commitment, and the Distinguished McKnight University Professorship of University of Minnesota to LNW.

References

  1. Feng X, Krogh KA, Wu C-Y, Lin Y-W, Tsai H-C, Thayer SA, et al. Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death. Nat Commun. 2014;5:4487.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Feng X, Lin Y-L, Wei L-N. Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation. Brain Behav Immun. 2015;46:270–9.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Flaisher-Grinberg S, Tsai HC, Feng X, Wei LN. Emotional regulatory function of receptor interacting protein 140 revealed in the ventromedial hypothalamus. Brain Behav Immun. 2014;40:226–34.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Ho P-C, Wei L-N. Biological activities of receptor-interacting protein 140 in adipocytes and metabolic diseases. Curr Diabetes Rev. 2012;8(6):452–7.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Ho P-C, Lin Y-W, Tsui Y-C, Gupta P, Wei L-N. A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160. Cell Metab. 2009;10(6):516–23.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Ho PC, Chang KC, Chuang YS, Wei LN. Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production. FASEB J. 2011;25(5):1758–66.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Ho P-C, Tsui Y-C, Feng X, Greaves DR, Wei L-N. NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance. Nat Immunol. 2012;13(4):379–86.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Huq MDM, Gupta P, Wei L-N. Post-translational modifications of nuclear co-repressor RIP140: a therapeutic target for metabolic diseases. Curr Med Chem. 2008;15(4):386–92.CrossRefGoogle Scholar
  9. Lee CH, Chinpaisal C, Wei LN. Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2. Mol Cell Biol. 1998;18(11):6745–55.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Lin Y-W, Lee B, Liu P-S, Wei L-N. Receptor-interacting protein 140 orchestrates the dynamics of macrophage M1/M2 polarization. J Innate Immun. 2016;8(1):97–107.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Lin Y-W, Liu P-S, Adhikari N, Hall JL, Wei L-N. RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages. J Mol Cell Cardiol. 2015b;79:287–94.CrossRefPubMedGoogle Scholar
  12. Liu P-S, Lin Y-W, Lee B, McCrady-Spitzer SK, Levine JA, Wei L-N. Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning, and prevents high-fat diet-induced insulin resistance. Diabetes. 2014;63(12):4021–31.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Liu P-S, Lin Y-W, Burton FH, Wei L-N. Injecting engineered anti-inflammatory macrophages therapeutically induces white adipose tissue browning and improves diet-induced insulin resistance. Adipocytes. 2015a;4(2):123–8.CrossRefGoogle Scholar
  14. Liu P-S, Lin Y-W, Burton FH, Wei L-N. M1-M2 balancing act in white adipose tissue browning – a new role for RIP140. Adipocytes. 2015b;4(2):146–8.CrossRefGoogle Scholar
  15. Park SW, Huang W-H, Persaud SD, Wei L-N. RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation. Nucleic Acids Res. 2009;37(21):7085–94.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Persaud SD, Huang W-H, Park SW, Wei L-N. Gene repressive activity of RIP140 through direct interaction with CDK8. Mol Endocrinol. 2011;25(10):1689–98.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Wei L-N. Retinoids and receptor interacting protein 140 (RIP140) in gene regulation. Curr Med Chem. 2004;11(12):1527–32.CrossRefPubMedGoogle Scholar
  18. White R, Leonardsson G, Rosewell I, Ann Jacobs M, Milligan S, Parker M. The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility. Nat Med. 2000;6(12):1368–74.CrossRefPubMedGoogle Scholar
  19. Wu C-Y, Feng X, Wei L-N. Coordinated repressive chromatin-remodeling of Oct4 and Nanog genes in RA-induced differentiation of embryonic stem cells involves RIP140. Nucleic Acids Res. 2014;42(7):4306–17.PubMedPubMedCentralCrossRefGoogle Scholar
  20. Wu C-Y, Persaud SD, Wei L-N. Retinoic acid induces ubiquitination-resistant RIP140/LSD1 complex to fine-tune Pax6 gene in neuronal differentiation. Stem Cells. 2016;34(1):114–23.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of Minnesota Medical SchoolMinneapolisUSA