Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Leopoldo Santos-ArgumedoEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_278


Historical Background

CD38, as many molecules described in this encyclopedia, was described and characterized in the period 1980–1990, using a mouse monoclonal antibody recognizing human CD38 (mAb) (OKT-10) developed by Ellie L. Reinherz et al. (1980). Through the use of this and many other mAbs, it was determined that CD38 is expressed in activated human T cells, plasma cells, and several lymphoid and myeloid cells as well as many cell malignancies. CD38 was rediscovered in mice by the mAb NIM-R5 developed by Mike Parkhouse and his group at the National Institute of Medical Research, Mill Hill, London, UK (Santos-Argumedo et al. 1993), and in conjunction with other tools, allowed its biochemical and biological characterization. Despite being a useful marker, very little was known about its function....

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Departamento de Biomedicina MolecularCentro de Investigación y de Estudios Avanzados (CINVESTAV-IPN)Mexico CityMexico