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Encyclopedia of Signaling Molecules pp 3291–3298Cite as

MYLK (Myosin Light Chain Kinase)

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Synonyms

MLCK; MLCK108; MLCK210; MYLK1; Nonmuscle myosin light chain kinase; smMLCK; Smooth muscle myosin light chain kinase

Historical Background

The gene for myosin light chain kinase encodes three proteins: MLCK210, MLCK108, and telokin/kinase-related protein (KRP). The first protein discovered was MLCK108 (Mr = 110–140 kDa) as a major cytoplasmic component of smooth muscle and responsible for smooth muscle contractility through the phosphorylation of the regulatory light chain of myosin (Lukas et al. 1998; Kamm and Stull 2001). MLCK210 (Mr = 210–220 kDa) has an amino-terminal extension containing additional protein-binding elements (Fig. 1). It was discovered ∼15 years later before the gene for MYLK was characterized from chicken (Birukov et al. 1998) and humans (Shen et al. 2012). Both MLCKs are Ca2+-calmodulin-dependent enzymes. Telokin/KRP is an independently expressed nonkinase gene product containing the C-terminus of MLCK, and functions as a myosin-binding and...

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Northwestern University, 303 E. Chicago Ave, Chicago, IL, 60611, USA

    Thomas J. Lukas

  2. Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex, Ministry of Healthcare of Russian Federation, Moscow, 3rd Cherepkovskaya St., 15a, 121552, Russia

    Vladimir P. Shirinsky

Authors
  1. Thomas J. Lukas
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  2. Vladimir P. Shirinsky
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Corresponding author

Correspondence to Thomas J. Lukas .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Lukas, T.J., Shirinsky, V.P. (2018). MYLK (Myosin Light Chain Kinase). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_248

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