Phosphoprotein enriched in astrocytes 15 kDa (PEA-15), also known as PED-15, is a 15 kDa protein that is highly expressed in the nervous system with particularly high levels in astrocytes and neurons of the hippocampus. Chneiweiss and colleagues first characterized PEA-15 as a major substrate for Protein Kinase C (PKC) in astrocytes and later cloned the cDNA encoding the protein (Araujo et al. 1993; Estelles et al. 1996). The first indications of the functional significance of PEA-15 was identified when it was shown to be a phosphoprotein overexpressed in skeletal muscle in patients with type 2 diabetes (Condorelli et al. 1998). In this context, PEA-15 was shown to inhibit insulin-stimulated glucose transport, indicating it may be involved in the development of type 2 diabetes. PEA-15...
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