Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

PTEN-Induced Kinase 1 (PINK1)

  • Laura M. Westrate
  • Jeffrey P. MacKeigan
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_206

Synonyms

 BRPK;  PARK6;  PINK1

Historical Background

The discovery of PTEN-induced kinase 1 (PINK1) was first described in 2001 by Valente et al. as a novel locus for autosomal recessive Parkinson’s Disease (PD). Termed PARK6, the new locus was identified in a genome-wide homozygosity screen performed in a Sicilian family with multiple PD-affected members (Valente et al. 2001, 2004). Localized to the mitochondria, PINK1 was the first nuclear-encoded mitochondrial protein to be implicated in PD pathogenesis and strongly suggests the role of mitochondrial pathomechanisms in PD (Valente et al. 2004). The precise mechanism by which PINK1 contributes to mitochondrial dysfunction, however, remains unclear as there remains a significant gap in knowledge in our understanding of the role of PINK1 in human disease.

First identified as a serine/threonine kinase with reported homology to the Ca2+/calmodulin family, PINK1 does not fall within any of the previously identified kinase families as...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Van Andel Graduate SchoolGrand RapidsUSA
  2. 2.Van Andel Research InstituteGrand RapidsUSA
  3. 3.Center for Cancer Genomics and Quantitative BiologyVan Andel Research InstituteGrand RapidsUSA