Neurotensin Receptor (NTSR)
Neurotensin was originally isolated from bovine hypothalamus by Carraway and Leeman in 1973 and was identified as a 13 amino acid peptide (Carraway and Leeman 1973). It was named “neurotensin” in view of its hypotensive activity. Neurotensin is produced by neurons in the central nervous system (CNS) and N cells of the gastrointestinal tract. Neurotensin acts as a hormone and a neurotransmitter or neuromodulator in the periphery and in the CNS, respectively. Neurotensin is involved in the regulation of a number of physiological functions such as analgesia, neurodevelopment, neurodegeneration, thermal regulation, metabolic regulation, pituitary hormone secretion, gastrointestinal motility, and inflammation. It was later discovered that neurotensin is also present in several types of tumors and is implicated in tumorigenesis and tumor progression. Thus, signaling pathways downstream of neurotensin could be a potential drug target for the...
- Ye Y, Long X, Zhang L, Chen J, Liu P, Li H, et al. NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma. Oncotarget. 2016;7(43):70303–22.PubMedPubMedCentralCrossRefGoogle Scholar