The gene PSMD7 encodes the protein RPN8, also known as S12. RPN8, the human homologue of Mov-34, is a non-ATPase component of the 19S regulatory complex (Dubiel et al. 1995). Two 19S regulatory complexes bind to each end of the 20S proteasome to form the 26S proteasome.
The proteasome plays an important role in the cell, but its mechanism of action is not well understood. Although the proteasome was first isolated in 1979 (DeMartino and Goldberg 1979), the essential role the proteasome plays within a cell was not realized until 1990 (Fujiwara et al. 1990). The proteasome is the main component in the intracellular protein degradation pathway. This pathway was once thought to be a relatively unimportant part of the cell, but is now recognized to play an important role in regulating the lifetime of cellular proteins (Spataro et al. 1998).
Degradation is an important process within the cell (Glickman and Ciechanover 2002). The ultimate state...
- Nussbaum AK, Dick TP, Keilholz W, Schirle M, Stevanovic S, Dietz K, Heinemeyer W, Groll M, Wolf DH, Huber R, Rammensee H-G, Schild H. Cleavage motifs of the yeast 20s proteasome β subunits deduced from digests of enolase 1. Proc Natl Acad Sci U S A. 1998;95:12504–9.PubMedPubMedCentralCrossRefGoogle Scholar
- van’t Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AAM, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415(6871):530–6.CrossRefGoogle Scholar