Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SAMSN1 (SAM Domain, SH3 Domain, and Nuclear Localization Signal)

  • Yuan Xiao Zhu
  • A. Keith Stewart
  • Jaime O. Claudio
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_191

Synonyms

 HACS1

Historical Background

The gene encoding SAMSN1 maps to human chromosome 21q11.2 in a region that is frequently disrupted by translocation events in hematopoietic malignancies (Mitelman et al. 1997). The full-length cDNA of human SAMSN1 was first identified and cloned in 2001 by two groups from myeloma cells and human cord blood–derived mast cells, named as HACS1 and Nash1, respectively (Claudio et al. 2001; Uchida et al. 2001). The predicted protein showed unique primary structure with a nuclear localization signal (NLS), a sterile alpha motif (SAM), and a Src homology 3 domain (SH3). SAMSN1 belongs to a novel family of scaffolding and adaptor proteins that includes SASH3/SLY/HACS2 (Beer et al. 2001) and SASH1/KIAA0790 (Zeller et al. 2003). The function of this novel family is not well characterized. The mouse, rat, and chimp orthologs have been identified, and unnamed protein homologs exist in chicken, zebrafish, and fly.

Expression of SAMSN1

SAMSN1 is expressed in...

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References

  1. Beer S, Simins AB, Schuster A, Holzmann B. Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells. Biochim Biophys Acta. 2001;1520(1):89–93.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Beer S, Scheikl T, Reis B, Hüser N, Pfeffer K, Holzmann B. Impaired immune responses and prolonged allograft survival in sly1 mutant mice. Mol Cell Biol. 2005;25(21):9646–60.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Claudio JO, Zhu YX, Benn SJ, Shukla AH, McGlade CJ, Falcioni N, Stewart AK. HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells. Oncogene. 2001;20(38):5373.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Gitton Y, Dahmane N, Baik S, Ruiz I, Altaba A, Neidhardt L, et al. HSA21 expression map initiative. A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002;420(6915):586–90.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Mitelman F, Mertens F, Johansson B. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet. 1997;15:417–74.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, et al. Human chromosome 21 gene expression atlas in the mouse. Nature. 2002;420(6915):582–6.CrossRefPubMedGoogle Scholar
  7. Rimkus C, Martini M, Friederichs J, Rosenberg R, Doll D, Siewert JR, et al. Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer. Br J Cancer. 2006;95(10):1419–23.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Uchida T, Nakao A, Nakano N, Kuramasu A, Saito H, Okumura K, et al. Identification of nash1, a novel protein containing a nuclear localization signal, a sterile alpha motif, and an SH3 domain preferentially expressed in mast cells. Biochem Biophys Res Commun. 2001;288(1):137–41.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Wang D, Stewart AK, Zhuang L, Zhu Y, Wang Y, Shi C, et al. Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1. FASEB J. 2010;24(3):947–56.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, et al. Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer. Genes Chromosomes Cancer. 2008;47(9):810–8.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, et al. SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer. Oncogene. 2003;22(19):2972–83.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, Trieu Y, et al. The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. J Exp Med. 2004;200(6):737–47.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Yuan Xiao Zhu
    • 1
  • A. Keith Stewart
    • 1
  • Jaime O. Claudio
    • 2
  1. 1.Division of Hematology-OncologyMayo ClinicScottsdaleUSA
  2. 2.Toronto General Research InstituteUniversity Health NetworkTorontoCanada