Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ARFRP1 (ADP-Ribosylation Factor Related Protein 1)

  • Deike HesseEmail author
  • Alexander Jaschke
  • Annette Schürmann
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_177

Historical Background

Due to the remote similarity of the ADP-ribosylation factor related protein 1 (ARFRP1) to other members of the ARF family, it was designated as a distant ARF family member (Fig. 1a). Discovered by the screening of adipocytes with degenerated primers for ARF proteins, ARFRP1 was shown to be highly conserved among species (97% identical amino acids between rat and human, 79% identical to Saccharomyces cerevisiae, and 74% identical to Drosophila melanogaster) and closest related to ARL1 (33% identical) and ARL3 (39% identical) (Schürmann et al. 1995, 1999). In comparison to the membrane association motif of other members of the ARF family (myristoylation), membrane association of ARFRP1 is mediated by acetylation of the initial methionine and interaction with an integral membrane protein Sys1 (Behnia et al. 2004; Setty et al. 2003). The Arfrp1gene consists of eight exons and is located on distal mouse chromosome 2 (human chromosome 20) with the transcriptional...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Deike Hesse
    • 1
    Email author
  • Alexander Jaschke
    • 1
  • Annette Schürmann
    • 1
  1. 1.Department of Experimental DiabetologyGerman Institute of Human Nutrition Potsdam-RehbrückeNuthetalGermany