PLD was first characterized in vegetables by Hanahan and Chaikoff (1947) and changes in its lipase activity have been reported in relation to lipid metabolism in seed germination and lipid turnover and lipid composition during plant development and in membrane deterioration as a result of stress injuries. PLD was first cloned from cabbage (Brassica oleracea), castor bean (Ricinus communis L.), rice (Oryza sativa L.), corn (Zea mays L.), and rockcress (Arabidopsis), which code for an 808-amino acid cytosolic protein of ∼90 kDa MW, as mentioned in the review by (Cockcroft 1996). Plant PLD is linked to membrane deterioration during plant senescence as a result of decreased membrane phospholipid content. Additionally, PLD is present in large quantities in bacteria (Streptomyces), yeast (Saccharomyces cerevisiae), and mammalian cells.
Within mammalian sources, PLD has been found in a variety of cell types...
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