Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ADCY9 (Adenylyl Cyclase 9)

  • Ferenc András Antoni
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_140

Synonyms

Historical Background

Adenylyl cyclase (AC) is the enzyme (EC 4.6.1.1) that converts Mg-ATP to adenosine 3′:5′ monophosphate or cyclic AMP and pyrophosphate first reported in 1958 by Sutherland and Rall. Eventually, a membrane-delimited biochemical cascade (Fig. 1) was discovered as the molecular machinery of signal transduction by cell surface receptors via heterotrimeric G proteins (Antoni 2000). The era of gene cloning revealed an unexpectedly complex structure of membrane-bound adenylyl cyclase: a single large polypeptide chain that crosses the plasma membrane 12 times, the catalytic core being formed between two structurally homologous cytoplasmic domains (C1a and C2a) held together by noncovalent interactions (Fig. 2). The crystal structures of these domains in complex with Gsα and the likely mechanisms underlying catalysis have been reported (Tesmer and Sprang 1998). There are nine genes...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre for Integrative PhysiologyUniversity of EdinburghEdinburghUK