Calcium Sensing Receptor (CASR)
The calcium-sensing receptor (CaSR) is a heterotrimeric G-protein-coupled receptor (GPCR), one of the largest family of cell-surface receptors, containing 14 other members including the metabotropic glutamate receptors (mGluR) and ɣ-aminobutyric acid (GABA) B receptors (Zhang et al. 2016a). CaSR was first cloned by Dr. Edward M. Brown in 1993 from the bovine parathyroid gland (Brown et al. 1993). The major function of CaSR is to maintain calcium homeostasis by balancing the ingestion and absorption of calcium in the gastrointestinal tract, excretion of calcium through the urinary system, and the breakdown and formation of bone. CaSR regulates parathyroid hormone (PTH) secretion from parathyroid glands and calcitonin secretion from thyroidal C-cells upon sensing the alteration of the extracellular calcium concentration (Zhang et al. 2016a). This...
This work was supported in part by National Institutes of Health Grants GM081749 and EB007268 and by the American Heart Association Grant 16GRNT31210016 (to J. J. Y.), and a Center for Diagnostics and Therapeutics fellowship (to R.G.) from Georgia State University.
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