Natriuretic Peptide Receptor Type B (NPRB)
The natriuretic peptides (NP) system is a family of peptides named A, B, and C-type natriuretic peptides (ANP, BNP, CNP) and urodilatin (URO), synthetized by the heart (ANP and BNP), kidney (URO), and vascular smooth muscle (CNP) but also by other cells widely dispersed in different organs and tissues (Koller and Goeddel 1992). The NP family plays an essential role on the regulation of blood pressure, the intravascular volume, and electrolyte homeostasis in mammals. Based on the fact that their main actions are exerted on regulation of the cardiovascular system, the NP are included within the big family of vasoactive peptides, together with angiotensin II, endothelins, bradikinin, and vasopressin among others (Padney 2015).
Binding of NP to either natriuretic peptide receptor type A (NPRA) or type B (NPRB) leads to activation of...
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