Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4)

  • Sarah N. Redmon
  • Koji Shibasaki
  • David KrižajEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101977


Historical Background

The transient receptor potential cation channel vanilloid isoform 4 (TRPV4), one of the six members of the TRPV subfamily, is a broadly expressed and versatile vertebrate cellular sensor. It was independently identified using candidate gene strategies as the vanilloid receptor-related osmotically activated channel (VR-OAC) in the central nervous system (CNS) (Liedtke et al. 2000) and the vanilloid receptor-like channel 2 (VRL-2) and osm-9-like TRP channel 4 (OTRPC4) in the kidney, liver, and heart (Strotmann et al. 2000). The gene encodes a nonselective cation channel with a slight preference for calcium (PCa/PNa= 6–10). The channel is a tetramer of four subunits that are...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sarah N. Redmon
    • 1
  • Koji Shibasaki
    • 2
  • David Križaj
    • 1
    Email author
  1. 1.Department of Ophthalmology and Visual SciencesJohn A. Moran Eye CenterSalt Lake CityUSA
  2. 2.Department of Molecular and Cellular NeurobiologyGunma University Graduate School of MedicineMaebashiJapan