The BUB1B gene encodes the protein budding uninhibited by benzimidazole-related 1 (BUBR1), a vital mitotic pseudokinase of the Spindle Assembly Checkpoint (SAC). This signaling pathway is responsible for delaying anaphase onset until all chromosome are properly attached to microtubules originating from opposing poles of the mitotic spindle, and prevents errors in chromosome segregation, which can lead to aneuploidy and chromosome instability, a pathogenic state with the potential to drive oncogenesis (Holland and Cleveland 2009; Kops et al. 2005).
Human BUBR1 was discovered through sequence-database searches in a study that aimed to identify the relationship between chromosomal instability, the SAC, and neoplasia (Cahill et al. 1998). BUBR1 is considered to be the human homolog of yeast Mitotic Arrest Deficient (MAD) 3 protein, although it was first thought to...
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