Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

IKK (IκB Kinase) Complex

  • Gilles Courtois
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101969

Synonyms

Historical Background

IKK ( B kinase) is the central regulator of the NF-κB signaling pathway, which plays a key role in immunity, inflammation, and cell survival (Karin and Ben-Neriah 2000; Hayden and Ghosh 2012). NF-κB is the generic name of a family of inducible dimeric transcription factors that are sequestered in the cytoplasm of resting cells by interaction with inhibitory protein IκBs. Upon cell stimulation ΙκBs are phosphorylated, and this modification triggers their ubiquitination and destruction by the proteasome. This allows free NF-κB proteins to translocate in the nucleus and to activate their target genes (Fig. 1).
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Notes

Acknowledgment

I thank Dr. Jérémie Gautheron for preparing Fig. 5.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.INSERM U1038/BGE/BIG, CEA GrenobleGrenobleFrance