Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ADP-Ribosylation Factor-6 (ARF6)

  • Salman Tamaddon-Jahromi
  • Venkateswarlu KanamarlapudiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101965


Historical Background

The first member of the ADP-ribosylation factor (ARF) family (ARF1) was originally discovered in 1984 as a cofactor for cholera toxin-mediated ADP-ribosylation of the heterotrimeric G-protein Gs (Kahn and Gilman 1984). Since then it has been found to be a Ras-related small GTPase with molecular weight of ~21 kDa (Sewell and Kahn 1988). Use of Saccharomyces cerevisiae as a model system allowed the determination of a role for ARF1 in the secretory pathway, along with its intracellular localization at the Golgi (Stearns et al. 1990). ARFs are ubiquitously expressed in eukaryotic cells and are major regulators of intercellular vesicle trafficking. They have been found to be conserved across many species, including yeast, fish, insects, and animals, indicating an important role for them in cellular functions. Subsequent characterization of the ARF family in mammals has...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Salman Tamaddon-Jahromi
    • 1
  • Venkateswarlu Kanamarlapudi
    • 1
    Email author
  1. 1.Institute of Life Science 1, School of MedicineSwansea UniversitySwansea, WalesUK