Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

TNFAIP3 (Tumor Necrosis Factor, Alpha-Induced Protein 3)

  • Rebecca McElroyEmail author
  • Madeleine Ennis
  • Bettina C. SchockEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101957


Historical Background

The intracellular ubiquitin-editing protein tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been characterized as a dual inhibitor in NF-κB signaling and cell death (Wertz et al. 2004). It is a primary response gene located on chromosome 6q23, originally identified as a gene in human umbilical vein endothelial cells whose expression is rapidly induced by tumor necrosis factor (TNF). The 80 kDa protein encoded by TNFAIP3 is the zinc finger protein A20, which has both ubiquitin ligase and deubiquitinase activities. A20, originally discovered in 1990, acts as a central and inducible endogenous negative feedback regulator of the NF-κB signaling pathway, the inappropriate activity of which has been linked to a host of autoimmune and inflammatory...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre for Experimental MedicineQueen’s University BelfastBelfastUK