Skip to main content
SpringerLink
Log in

TRPM1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 85 Accesses

Synonyms

Csnb1C; Ltrpc1; Melastatin 1 (Mlsn1); Transient receptor potential cation channel subfamily M member 1

Historical Background

The transient receptor potential (TRP) channels play a diverse range of essential roles in the sensory systems of various species, including both invertebrates and vertebrates. The TRP channel was first identified as a molecule required for proper light response in Drosophila melanogaster. Thereafter, a series of TRP family proteins have been identified. Recently, TRPM1, the founding member of the melanoma-related transient receptor potential (TRPM) subfamily, was shown to be required for the photoresponse in mouse retinal ON bipolar cells. It further proved that TRPM1 is a component of the transduction cation channel negatively regulated by the metabotropic glutamate receptor 6 (mGluR6) cascade in ON bipolar cells through a reconstitution experiment using CHO cells expressing TRPM1, mGluR6, and Goα. In addition to the function of visual transduction...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Audo I, Robson AG, Holder GE, Moore AT. The negative ERG: clinical phenotypes and disease mechanisms of inner retinal dysfunction. Surv Ophthalmol. 2008;53:16–40.

    Article  PubMed  Google Scholar 

  • Bellone RR, Brooks SA, Sandmeyer L, Murphy BA, Forsyth G, Archer S, Bailey E, Grahn B. Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics. 2008;179:1861–70.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cao Y, Posokhova E, Martemyanov KA. TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner. J Neurosci. 2011;31:11521–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dhingra A, Fina ME, Neinstein A, Ramsey DJ, Xu Y, Fishman GA, Alexander KR, Qian H, Peachey NS, Gregg RG, Vardi N. Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells. J Neurosci. 2011;31:3962–7.

    Article  PubMed  CAS  Google Scholar 

  • Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res. 1998;58:1515–20.

    PubMed  CAS  Google Scholar 

  • Iwakabe H, Katsuura G, Ishibashi C, Nakanishi S. Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse. Neuropharmacology. 1997;36:135–43.

    Article  PubMed  CAS  Google Scholar 

  • Koike C, Sanuki R, Miyata K, Koyasu T, Miyoshi T, Sawai H, Kondo M, Usukura J, Furukawa T. The functional analysis of TRPM1 in retinal bipolar cells. Neurosci Res. 2007;58:S41.

    Article  Google Scholar 

  • Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T. TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A. 2010a;107:332–7.

    Article  PubMed  Google Scholar 

  • Koike C, Numata T, Ueda H, Mori Y, Furukawa T. TRPM1: A vertebrate TRP channel responsible for retinal ON bipolar function. Cell Calcium. 2010b;48:95–101.

    Article  PubMed  CAS  Google Scholar 

  • Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T. Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. PLoS One. 2011;6:e19911.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li Z, Sergouniotis PI, Michaelides M, Mackay DS, Wright GA, Devery S, Moore AT, Holder GE, Robson AG, Webster AR. Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans. Am J Hum Genet. 2009;85:711–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, Nakanishi S. Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell. 1995;80:757–65.

    Article  PubMed  CAS  Google Scholar 

  • Montell C, Jones K, Hafen E, Rubin G. Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science. 1985;230:1040–3.

    Article  PubMed  CAS  Google Scholar 

  • Morigiwa K, Vardi N. Differential expression of ionotropic glutamate receptor subunits in the outer retina. J Comp Neurol. 1999;405:173–84.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura M, Sanuki R, Yasuma TR, Onishi A, Nishiguchi KM, Koike C, Kadowaki M, Kondo M, Miyake Y, Furukawa T. TRPM1 mutations are associated with the complete form of congenital stationary night blindness. Mol Vis. 2010;16:425–37.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Nakanishi S, Nakajima Y, Masu M, Ueda Y, Nakahara K, Watanabe D, Yamaguchi S, Kawabata S, Okada M. Glutamate receptors: brain function and signal transduction. Brain Res Brain Res Rev. 1998;26:230–5.

    Article  PubMed  Google Scholar 

  • Nawy S. The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells. J Neurosci. 1999;19:2938–44.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Neuillé M, Morgans CW, Cao Y, Orhan E, Michiels C, Sahel JA, Audo I, Duvoisin RM, Martemyanov KA, Zeitz C. LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur J Neurosci. 2015;42:1966–75.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal. 2009;2:ra21.

    PubMed  PubMed Central  Google Scholar 

  • Orlandi C, Cao Y, Martemyanov KA. Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling Cascade in retina ON-bipolar neurons. Invest Ophthalmol Vis Sci. 2013;54:7153–61.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pearring JN, Bojang P, Shen Y, Koike C, Furukawa T, Nawy S, Gregg RG. A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites. J Neurosci. 2011;31:10060–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shen Y, Rampino MA, Carroll RC, Nawy S. G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer. Proc Natl Acad Sci U S A. 2012;109:8752–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shiells RA, Falk G, Naghshineh S. Action of glutamate and aspartate analogues on rod horizontal and bipolar cells. Nature. 1981;294:592–4.

    Article  PubMed  CAS  Google Scholar 

  • Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol. 2013;30:2725–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tsuruda PR, Julius D, Minor DL. Coiled coils direct assembly of a cold-activated TRP channel. Neuron. 2006;51:201–12.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem. 2007;76:387–417.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xu Y, Orlandi C, Cao Y, Yang S, Choi CI, Pagadala V, Birnbaumer L, Martemyanov KA, Vardi N. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Sci Rep. 2016;6:20940.

    Google Scholar 

Download references

Acknowledgments

TRPM1-related work conducted in the authors’ laboratory is supported by the CREST from Japan Science and Technology Agency, Grant-in-Aid for Scientific Research (B), Takeda Science Foundation, Koyanagi Foundation, and Terumo Foundation for Life Science and Arts Life Science support program.

Author information

Authors and Affiliations

  1. Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Tetsuo Kon & Takahisa Furukawa

Authors
  1. Tetsuo Kon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takahisa Furukawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takahisa Furukawa .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Kon, T., Furukawa, T. (2018). TRPM1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101948

Download citation

Publish with us

Policies and ethics

Search

Navigation