Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Transient Receptor Potential Cation Channel Subfamily A Member 1 (TRPA1)

  • Francesco De LoguEmail author
  • Pierangelo Geppetti
  • Romina Nassini
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101937


Historical Background and Structure

The transient receptor potential ankyrin-1 (TRPA1) is the only member of TRPA channel subfamily in mammals. Initially identified in human lung fibroblasts (Jaquemar et al. 1999), as an ankyrin-like protein with transmembrane domains protein 1 (ANKTM1), it was successively recognized as a TRP channel for its homology with several members of the same superfamily (Story et al. 2003). TRPA1 that has been cloned in invertebrates, such as Caenorhabditis elegans and fruit fly, and in a variety of species, including zebrafish, chicken, mouse, rat, dog, and humans (Nilius and Szallasi 2014), is a protein of about 1100 amino acids (120–130 kDa), although shorter splice variants have also been reported. The human trpa1gene is in chromosome 8q13 and consists of 27 exons and spans 55,701 base pairs. Like other...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Francesco De Logu
    • 1
    Email author
  • Pierangelo Geppetti
    • 1
  • Romina Nassini
    • 1
  1. 1.Department of Health Sciences, Pharmacology and Oncology UnitUniversity of FlorenceFlorenceItaly