The basic leucine-zipper transcription factor, ATF-like (BATF) was first identified from a cDNA library of Epstein-Barr virus (EBV)-stimulated B cells, as a nuclear protein containing a basic leucine-zipper motif. A strong hybridization band for BATF was detected in poly-adenylated mRNA from cell lines and several human tissues such as the lung and Raji Burkitt’s lymphoma by Northern Blot analysis (Dorsey et al. 1995). Only a few months later, another study described a new bZIP transcription factor, which they called SF-HT-activated gene 2 (SFA-2), which was found highly expressed in T and B cells, especially when these cells were transformed by human T cell leukemia virus type I (HTLV-I) (Hasegawa et al. 1996).
Both studies showed that BATF does not form homodimers but builds heterodimers preferentially with...
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