Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Epidermal Growth Factor (EGF)

  • Sigrid A. Langhans
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101919

Synonyms

Historical Background

Epidermal growth factor (EGF) is a growth factor best known for its ability to stimulate cell growth and proliferation. EGF was discovered as a result of the initial observations of Stanley Cohen and coworkers in the 1950s (Cohen 1986) in which the injection of extracts from mouse salivary glands into newborn mice resulted in precocious eyelid opening and tooth eruption. Subsequent studies revealed more generalized biological effects of salivary gland extracts, including enhancement of epidermal growth and keratinization. The factor mediating these effects was identified as a 6-kDa peptide of 53 amino acids and was thus named the epidermal growth factor. In later years and independent of these studies, urogastrone, long known as inhibitor of gastric acid secretion, was isolated from urine and found to be the human form of mouse EGF. EGF has now been detected in various additional body fluids and tissues including milk, urine,...

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References

  1. Carpenter G, Cohen S. Epidermal growth factor. Annu Rev Biochem. 1979;48:193–216.  https://doi.org/10.1146/annurev.bi.48.070179.001205.CrossRefPubMedGoogle Scholar
  2. Cohen S. Nobel lecture. Epidermal growth factor. Biosci Rep. 1986;6:1017–28.CrossRefPubMedGoogle Scholar
  3. Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA. The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis. Atherosclerosis. 2006;186:38–53.  https://doi.org/10.1016/j.atherosclerosis.2005.06.038.CrossRefPubMedGoogle Scholar
  4. Edwin F, Wiepz GJ, Singh R, Peet CR, Chaturvedi D, Bertics PJ, et al. A historical perspective of the EGF receptor and related systems. Methods Mol Biol. 2006;327:1–24.PubMedGoogle Scholar
  5. Forrester SJ, Kawai T, O’Brien S, Thomas W, Harris RC, Eguchi S. Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system. Annu Rev Pharmacol Toxicol. 2016;56:627–53.  https://doi.org/10.1146/annurev-pharmtox-070115-095427.CrossRefPubMedGoogle Scholar
  6. Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H, Matsushita N. Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Sci. 2008;99:214–20.  https://doi.org/10.1111/j.1349-7006.2007.00676.x. CAS676 [pii].CrossRefPubMedGoogle Scholar
  7. Lemmon MA, Schlessinger J, Ferguson KM. The EGFR family: not so prototypical receptor tyrosine kinases. Cold Spring Harb Perspect Biol. 2014;6:a020768. doi: 10.1101/cshperspect.a020768 a020768. [pii] 6/4/a020768 [pii].CrossRefPubMedPubMedCentralGoogle Scholar
  8. Lindsey S, Langhans SA. Crosstalk of oncogenic signaling pathways during epithelial-mesenchymal transition. Front Oncol. 2014;4:358.  https://doi.org/10.3389/fonc.2014.00358.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Sanderson MP, Dempsey PJ, Dunbar AJ. Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors. Growth Factors. 2006;24:121–36.  https://doi.org/10.1080/08977190600634373.CrossRefPubMedGoogle Scholar
  10. Singh B, Carpenter G, Coffey RJ. EGF receptor ligands: recent advances. F1000Res. 2016;5.  https://doi.org/10.12688/f1000research.9025.1.
  11. Tebbutt N, Pedersen MW, Johns TG. Targeting the ERBB family in cancer: couples therapy. Nat Rev Cancer. 2013;13:663–73.  https://doi.org/10.1038/nrc3559.CrossRefPubMedGoogle Scholar
  12. Tomas A, Futter CE, Eden ER. EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol. 2014;24:26–34.  https://doi.org/10.1016/j.tcb.2013.11.002.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Zeng F, Harris RC. Epidermal growth factor, from gene organization to bedside. Semin Cell Dev Biol. 2014;28:2–11.  https://doi.org/10.1016/j.semcdb.2014.01.011.CrossRefPubMedGoogle Scholar
  14. Zheng K, Kitazato K, Wang Y. Viruses exploit the function of epidermal growth factor receptor. Rev Med Virol. 2014;24:274–86.  https://doi.org/10.1002/rmv.1796.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Nemours Center for Childhood Cancer ResearchNemours/Alfred I duPont Hospital for ChildrenWilmingtonUSA