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Pyruvate Kinase M2

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  • First Online:
Encyclopedia of Signaling Molecules

Synonyms

M2-PK; OIP3; PK2; PK3; PKM2; Pyruvate kinase Muscle; THBP1

Historical Background

PKM2 (pyruvate kinase muscle isoform 2) is an isoform of pyruvate kinase (PK; ATP, pyruvate 2-O-phosphotranferase; EC 2.7.1.40), a terminal glycolytic enzyme that catalyzes an irreversible, rate-limiting transphosphorylation reaction between phosphoenolpyruvate (PEP) and adenosine diphosphate (ADP) to generate pyruvate and ATP, accounting for net glycolytic energy (ATP) generation (Mazurek 2011). Consumption of pyruvate in a number of pathways places this enzyme at a crucial metabolic intersection. PK is ubiquitously present in simple to complex organisms. In organisms where PK is absent, its function is fulfilled by another homologue, pyruvate phosphate dikinase (PPDK) (Saavedra-Lira et al. 1998). In most bacteria and lower eukaryotes, only one form of PK is found, although many bacteria have two isozymes. In plants, PK exists in the form of cytoplasmic and plastid isoforms, and in vertebrate...

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Authors and Affiliations

  1. National Center for Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Gopinath Prakasam, Mohammad Askandar Iqbal, Vibhor Gupta, Bhupender Kumar & Rameshwar N. K. Bamezai

  2. Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, 110025, India

    Mohammad Askandar Iqbal

Authors
  1. Gopinath Prakasam
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  2. Mohammad Askandar Iqbal
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  3. Vibhor Gupta
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  4. Bhupender Kumar
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  5. Rameshwar N. K. Bamezai
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Corresponding author

Correspondence to Rameshwar N. K. Bamezai .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Prakasam, G., Iqbal, M.A., Gupta, V., Kumar, B., Bamezai, R.N.K. (2018). Pyruvate Kinase M2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101893

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