Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Synapsins (SYN)

  • Sang-Ho Song
  • George J. AugustineEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101889


Historical Background

Synapsins were the first proteins identified in presynaptic terminals: Paul Greengard and colleagues identified protein I (now synapsin I, Kuo and Greengard 1969) as a major neuronal substrate for the cyclic AMP-dependent protein kinase (PKA) in rat brain (Johnson et al. 1972; Ueda et al. 1973). Protein I was also the first identified substrate of the Ca 2+/calmodulin-dependent protein kinase (De Camilli et al. 1990), indicating that synapsins serve as a central hub of numerous protein kinase signaling pathways (see below). Early on, it was appreciated that there are multiple synapsins; two isoforms, protein Ia (86 kDa) and Ib (80 kDa), could be distinguished by their molecular weights (Forn and Greengard 1978). We now know that there are even more synapsin isoforms (see Fig. 1). Protein I was found to be enriched in presynaptic terminals and bound to synaptic vesicles within these terminals, causing it to be renamed synapsin I...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Lee Kong Chian School of MedicineNanyang Technological UniversitySingaporeSingapore
  2. 2.Institute of Molecular and Cell BiologyA*STARSingaporeSingapore