Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

TRPM4

  • Romain Guinamard
  • Christophe Simard
  • Laurent Sallé
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101882

Synonyms

Historical Background

Transient receptor potential, subfamily M(melastatin-related), member 4 (TRPM4) gene encodes a channel protein responsible for a Ca2+-activated nonselective cationic (NSCCa) current. Electrophysiological signatures of such currents are known since the beginning of patch clamp single-channel recordings. They were observed in a wide variety of tissues in the 1980s to 2000s, including epithelia, secretory tissues, or excitable cells (neurons and myocytes) (see Guinamard et al. 2011for review). However, these currents remained orphaned until the cloning of the TRP gene family at the end of the 1990s. Among these, TRPM1 (melastatin) has been cloned in 1998 and opened the way for the new subfamily TRPM which is composed of eight members (1–8). Based on homology sequence screening of a cDNA library, Xu et al. identified a first sequence of the TRPM4 gene in...

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References

  1. Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, et al. The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat Immunol. 2008;9:1148–56.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Caffes N, Kurland DB, Gerzanich V, Simard JM. Glibenclamide for the treatment of ischemic and hemorrhagic stroke. Int J Mol Sci. 2015;16:4973–84.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Cho CH, Lee YS, Kim E, Hwang EM, Park JY. Physiological functions of the TRPM4 channels via protein interactions. BMB Rep. 2015;48:1–5.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Constantine M, Liew CK, Lo V, Macmillan A, Cranfield CG, Sunde M, et al. Heterologously-expressed and liposome-reconstituted human transient receptor potential melastatin 4 channel (TRPM4) is a functional tetramer. Sci Report. 2016;6:19352.CrossRefGoogle Scholar
  5. Earley S. TRPM4 channels in smooth muscle function. Pflugers Arch. 2013;465:1223–31.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Funk GD. I think I (CAN): modulation of TRPM4 channels may contribute not only to the emergence of rhythm, but robust output and metabolic sensitivity of the preBötzinger Complex inspiratory network. J Physiol. 2013;591:1593–4.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Grand T, Demion M, Norez C, Mettey Y, Launay P, Becq F, et al. 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br J Pharmacol. 2008;153:1697–705.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Guinamard R, Sallé L, Simard C. The non-selective monovalent cationic channels TRPM4 and TRPM5. Adv Exp Med Biol. 2011;704:147–71.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Guinamard R, Bouvagnet P, Hof T, Liu H, Simard C, Sallé L. TRPM4 in cardiac electrical activity. Cardiovasc Res. 2015;108:21–30.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Hristov KL, Smith AC, Parajuli SP, Malysz J, Rovner ES, Petkov GV. Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function. Am J Phys Cell Physiol. 2016;310:C600–11.CrossRefGoogle Scholar
  11. Islam MS. TRP channels of islets. Adv Exp Med Biol. 2011;704:811–30.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Kruse M, Schulze-Bahr E, Corfield V, Beckmann A, Stallmeyer B, Kurtbay G, et al. Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. J Clin Invest. 2009;119:2737–44.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP. TRPM4 is a Ca2+−activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002;109:397–407.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Mathar I, Jacobs G, Kecskes M, Menigoz A, Philippaert K, Vennekens R. Trpm4. Handb Exp Pharmacol. 2014;222:461–87.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Nilius B, Prenen J, Droogmans G, Voets T, Vennekens R, Freichel M, et al. Voltage dependence of the Ca2+ – activated cation channel TRPM4. J Biol Chem. 2003;278:30813–20.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Sheth KN, Simard JM, Elm J, Kronenberg G, Kunte H, Kimberly WT. Human data supporting glyburide in ischemic stroke. Acta Neurochir Suppl. 2016;121:13–8.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015;125:4714–28.PubMedPubMedCentralCrossRefGoogle Scholar
  18. Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B. Comparison of functional properties of the Ca2+ – activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium. 2005;37:267–78.CrossRefGoogle Scholar
  19. Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, et al. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol. 2007;8:312–20.PubMedPubMedCentralCrossRefGoogle Scholar
  20. Xu XZ, Moebius F, Gill DL, Montell C. Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci USA. 2001;98:10692–7.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Romain Guinamard
    • 1
  • Christophe Simard
    • 1
  • Laurent Sallé
    • 1
  1. 1.Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardiqueNormandie Univ, UNICAENCaenFrance