Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

TRPV3 (Transient Receptor Potential Channel Subfamily V Member 3)

  • Jialie Luo
  • Hongzhen Hu
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101877

Synonyms

Historical Background

TRPV3, a member of the subfamily V of transient receptor potential (TRP) channel family, was first identified as a temperature-sensitive nonselective cation channel by three independent research groups (Smith et al. 2002; Xu et al. 2002; Peier et al. 2002). TRPV3 channels have a large unitary conductance of about 150–200 pS and share 43% sequence homology with TRPV1, the capsaicin receptor. Like many other TRP channels, TRPV3 is a tetramer, and each subunit is composed of six transmembrane (TM) domains. The putative pore loop is located between TM5 and TM6 (Xu et al. 2002). TRPV3 is preferentially permeable to Ca2+, and its permeability ratio of Ca2+/Na+ is estimated to be around 10–15. Functional TRPV3 channel is present in both neuronal and non-neuronal tissues with a prominent expression in the skin, where it plays important roles in skin physiology and disease (Smith et al. 2002).

Activation and...

This is a preview of subscription content, log in to check access.

References

  1. Asakawa M, Yoshioka T, Matsutani T, Hikita I, Suzuki M, Oshima I, Tsukahara K, Arimura A, Horikawa T, Hirasawa T, Sakata T. Association of a mutation in TRPV3 with defective hair growth in rodents. J Invest Dermatol. 2006;126:2664–72.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Borbiro I, Lisztes E, Toth BI, Czifra G, Olah A, Szollosi AG, Szentandrassy N, Nanasi PP, Peter Z, Paus R, Kovacs L, Biro T. Activation of transient receptor potential vanilloid-3 inhibits human hair growth. J Invest Dermatol. 2011;131:1605–14.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010;141:331–43.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Firlej V, Mathieu JR, Gilbert C, Lemonnier L, Nakhle J, Gallou-Kabani C, Guarmit B, Morin A, Prevarskaya N, Delongchamps NB, Cabon F. Thrombospondin-1 triggers cell migration and development of advanced prostate tumors. Cancer Res. 2011;71:7649–58.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Grandl J, Hu HZ, Bandell M, Bursulaya B, Schmidt M, Petrus M, Patapoutian A. Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci. 2008;11:1007–13.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Hoeft B, Linseisen J, Beckmann L, Muller-Decker K, Canzian F, Husing A, Kaaks R, Vogel U, Jakobsen MU, Overvad K, Hansen RD, Knuppel S, Boeing H, Trichopoulou A, Koumantaki Y, Trichopoulos D, Berrino F, Palli D, Panico S, Tumino R, Bueno-de-Mesquita HB, van Duijnhoven FJ, van Gils CH, Peeters PH, Dumeaux V, Lund E, Huerta Castano JM, Munoz X, Rodriguez L, Barricarte A, Manjer J, Jirstrom K, Van Guelpen B, Hallmans G, Spencer EA, Crowe FL, Khaw KT, Wareham N, Morois S, Boutron-Ruault MC, Clavel-Chapelon F, Chajes V, Jenab M, Boffetta P, Vineis P, Mouw T, Norat T, Riboli E, Nieters A. Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. Carcinogenesis. 2010;31:466–72.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Jariwala U, Prescott J, Jia L, Barski A, Pregizer S, Cogan JP, Arasheben A, Tilley WD, Scher HI, Gerald WL, Buchanan G, Coetzee GA, Frenkel B. Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer. 2007;6:39.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Kim HO, Cho YS, Park SY, Kwak IS, Choi MG, Chung BY, Park CW, Lee JY. Increased activity of TRPV3 in keratinocytes in hypertrophic burn scars with post burn pruritus. Wound Repair Regen. 2016;24:841–50.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Li XL, Zhang QH, Fan K, Li BY, Li HF, Qi HP, Guo J, Cao YG, Sun HL. Overexpression of TRPV3 correlates with tumor progression in non-small cell lung cancer. Int J Mol Sci. 2016;17:437.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Lin ZM, Chen Q, Lee MY, Cao X, Zhang J, Ma DL, Chen L, Hu XP, Wang HJ, Wang XW, Zhang P, Liu XZ, Guan LP, Tang YQ, Yang HZ, Tu P, Bu DF, Zhu XJ, Wang KW, Li RY, Yang Y. Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am J Hum Genet. 2012;90:558–64.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Luo J, Hu H. Thermally activated TRPV3 channels. Curr Top Membr. 2014;74:325–64.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Marics I, Malapert P, Reynders A, Gaillard S, Moqrich A. Acute heat-evoked temperature sensation is impaired but not abolished in mice lacking TRPV1 and TRPV3 channels. PLoS One. 2014;9:e99828.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KS, Andahazy M, Story GM, Patapoutian A. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science. 2005;307:1468–72.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A. A heat-sensitive TRP channel expressed in keratinocytes. Science. 2002;296:2046–9.CrossRefGoogle Scholar
  15. Pires PW, Sullivan MN, Pritchard HAT, Robinson JJ, Earley S. Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles. Am J Physiol Heart Circ Physiol. 2015;309:H2031–41.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Smith GD, Gunthorpe J, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 2002;418:186–90.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Xiao R, Tang JS, Wang CB, Colton CK, Tian JB, Zhu MX. Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J Biol Chem. 2008;283:6162–74.PubMedPubMedCentralCrossRefGoogle Scholar
  18. Xu HX, Ramsey IS, Kotecha SA, Moran MM, Chong JHA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 2002;418:181–6.CrossRefGoogle Scholar
  19. Yamamoto-Kasai E, Imura K, Yasui K, Shichijou M, Oshima I, Hirasawa T, Sakata T, Yoshioka T. TRPV3 as a therapeutic target for itch. J Invest Dermatol. 2012;132:2109–12.PubMedPubMedCentralCrossRefGoogle Scholar
  20. Yoshioka T, Imura K, Asakawa M, Suzuki M, Oshima I, Hirasawa T, Sakata T, Horikawa T, Arimura A. Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice. J Invest Dermatol. 2009;129:714–22.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.The Center for the Study of Itch, Department of AnesthesiologyWashington University in Saint LouisSaint LouisUSA