Synaptojanin 1 (SYNJ1) was discovered in 1994 as a brain-specific 145 kDa protein interacting with growth factor receptor-bound protein 2 (Grb2) and the phosphoprotein dynamin, involved in synaptic vesicle endocytosis and recycling (McPherson et al. 1994). SYNJ1 is a multidomain protein with a dual phosphoinositide phosphatase activity and is required for proper synaptic activity. Due to its high concentration in nerve terminals, its role in endocytosis has been widely studied and will be developed further in this article, but other unexpected roles are now emerging in different cell types and model organisms. In addition to its presynaptic functions, SYNJ1 is involved in internalization of AMPA...
- Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, et al. The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. J Biol Chem. 1999;274(45):32001–7.PubMedPubMedCentralCrossRefGoogle Scholar
- Dong Y, Gou Y, Li Y, Liu Y, Bai J. Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism. eLife. 2015; 4. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435004/
- Drouet V, Lesage S. Synaptojanin 1 mutation in Parkinson’s disease brings further insight into the neuropathological mechanisms. Biomed Res Int. 2014;2014. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181773/
- George AA, Hayden S, Stanton GR, Brockerhoff SE. Arf6 and the 5′phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptors. Cell. 2016;1(2):117–33.Google Scholar