Synapsin II (SYN2) was identified in the late 1970s following studies that began searching for neuronal substrates for endogenous cyclic adenosine 3′:5′ monophosphate (cAMP)-dependent phosphorylation. cAMP had been suggested to mediate neurotransmitter regulation through synaptic membrane proteins and led to the discovery of several proteins including the family of synapsin proteins. Highly specific to nerve terminals, synapsins were among one of the first identified synaptic vesicle-associated protein families (De Camilli et al. 1990).
The first member identified in the synapsin family was synapsin I, initially named protein I, and described by Paul Greengard in 1972 as a primary synaptic membrane phosphorylation target by cAMP-dependent kinases (Johnson et al. 1972). Following the discovery of synapsin I, a second member of the synapsin family – protein III – later renamed synapsin II (SYN2) was identified in the late 1970s...
The work described in this review was supported by the Canadian Institute of Health Research (CIHR).
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