Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Dong-Mei ZhaoEmail author
  • Hai-Hui Xue
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101862


Historical Background

Tcf1 transcription factor is a member of the Tcf/Lef family which consists of four members in vertebrates. Its orthologs in invertebrates include dTCF/pangolin in Drosophila and POP-1 in C. elegans (Arce et al. 2006; Cadigan 2012). Tcf1 was molecularly cloned in 1991 and found to be most abundantly expressed in T lymphocytes. In 1996, Lef1, a close homologue of Tcf1, was found to interact with β-catenin which is posttranslationally regulated by the Wnt signaling pathway. Since then, Tcf1, together with other members of Tcf/Lef family, is considered a Wnt effector transcription factor (Klaus and Birchmeier 2008). However, research efforts over the past two-and-half decades have revealed that Tcf1 interacts with several other transcription factors and cofactors, in addition to β-catenin, to cooperatively regulate gene transcription (Steinke and Xue 2014).


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Internal MedicineIowa City Veteran Affairs Health Care SystemsIowa CityUSA
  2. 2.Department of Microbiology, Carver College of MedicineUniversity of IowaIowa CityUSA